Ontology highlight
ABSTRACT:
SUBMITTER: Fu X
PROVIDER: S-EPMC3711551 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Fu Xiaoqin X Brown Kristy J KJ Yap Chan Choo CC Winckler Bettina B Jaiswal Jyoti K JK Liu Judy S JS
The Journal of neuroscience : the official journal of the Society for Neuroscience 20130101 2
Doublecortin (Dcx) is the causative gene for X-linked lissencephaly, which encodes a microtubule-binding protein. Axon tracts are abnormal in both affected individuals and in animal models. To determine the reason for the axon tract defect, we performed a semiquantitative proteomic analysis of the corpus callosum in mice mutant for Dcx. In axons from mice mutant for Dcx, widespread differences are found in actin-associated proteins as compared with wild-type axons. Decreases in actin-binding pro ...[more]