Ontology highlight
ABSTRACT:
SUBMITTER: Lee WL
PROVIDER: S-EPMC4745138 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Lee Wei Lin WL Grimes Jonathan M JM Robinson Robert C RC
Nature structural & molecular biology 20150209 3
Pathogenic Yersinia species evade host immune systems through the injection of Yersinia outer proteins (Yops) into phagocytic cells. One Yop, YopO, also known as YpkA, induces actin-filament disruption, impairing phagocytosis. Here we describe the X-ray structure of Yersinia enterocolitica YopO in complex with actin, which reveals that YopO binds to an actin monomer in a manner that blocks polymerization yet allows the bound actin to interact with host actin-regulating proteins. SILAC-MS and bio ...[more]