Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model.
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ABSTRACT:
SUBMITTER: Coppieters KT
PROVIDER: S-EPMC3712024 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
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Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model.
Coppieters Ken T KT Amirian Natalie N Pagni Philippe P PP Baca Jones Carmen C Wiberg Anna A Lasch Stanley S Hintermann Edith E Christen Urs U von Herrath Matthias G MG
Diabetes 20130222 7
Cytotoxic T lymphocytes (CTLs) constitute a major effector population in pancreatic islets from patients suffering from type 1 diabetes (T1D) and thus represent attractive targets for intervention. Some studies have suggested that blocking the interaction between the chemokine CXCL10 and its receptor CXCR3 on activated CTLs potently inhibits their recruitment and prevents β-cell death. Since recent studies on human pancreata from T1D patients have indicated that both ligand and receptor are abun ...[more]
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