Ontology highlight
ABSTRACT:
SUBMITTER: Montane J
PROVIDER: S-EPMC3148722 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Montane Joel J Bischoff Loraine L Soukhatcheva Galina G Dai Derek L DL Hardenberg Gijs G Levings Megan K MK Orban Paul C PC Kieffer Timothy J TJ Tan Rusung R Verchere C Bruce CB
The Journal of clinical investigation 20110801 8
Type 1 diabetes is characterized by destruction of insulin-producing β cells in the pancreatic islets by effector T cells. Tregs, defined by the markers CD4 and FoxP3, regulate immune responses by suppressing effector T cells and are recruited to sites of action by the chemokine CCL22. Here, we demonstrate that production of CCL22 in islets after intrapancreatic duct injection of double-stranded adeno-associated virus encoding CCL22 recruits endogenous Tregs to the islets and confers long-term p ...[more]