Ontology highlight
ABSTRACT:
SUBMITTER: Ishikawa F
PROVIDER: S-EPMC3713789 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Ishikawa Fumihiro F Haushalter Robert W RW Lee D John DJ Finzel Kara K Burkart Michael D MD
Journal of the American Chemical Society 20130604 24
Acyl carrier proteins (ACPs) play a central role in acetate biosynthetic pathways, serving as tethers for substrates and growing intermediates. Activity and structural studies have highlighted the complexities of this role, and the protein-protein interactions of ACPs have recently come under scrutiny as a regulator of catalysis. As existing methods to interrogate these interactions have fallen short, we have sought to develop new tools to aid their study. Here we describe the design, synthesis, ...[more]