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Rejuvenation of regeneration in the aging central nervous system.

ABSTRACT: Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life.

SUBMITTER: Ruckh JM

PROVIDER: S-EPMC3714794 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Rejuvenation of regeneration in the aging central nervous system.

Ruckh Julia M JM Zhao Jing-Wei JW Shadrach Jennifer L JL van Wijngaarden Peter P Rao Tata Nageswara TN Wagers Amy J AJ Franklin Robin J M RJ

Cell stem cell 20120101 1

Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restor ...[more]

PMID: 22226359

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