CXCR4-based imaging agents.
Ontology highlight
ABSTRACT:
SUBMITTER: Woodard LE
PROVIDER: S-EPMC3715079 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
CXCR4-based imaging agents.
Woodard Lauren E LE Nimmagadda Sridhar S
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20111101 11
Chemokine receptor 4 (CXCR4)-chemokine ligand 12 (CXCL12) interactions have been shown to play key roles in cancer cell survival, proliferation, chemotaxis, homing, adhesion, tumor angiogenesis, and resistance to conventional and targeted therapies. Given its extensive involvement in cancer progression, the CXCR4-CXCL12 axis has been considered a therapeutic target. Several inhibitors blocking this signaling cascade are in phase I trials. Because CXCR4 is constitutively expressed in a wide varie ...[more]
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