Ontology highlight
ABSTRACT:
SUBMITTER: Gao Z
PROVIDER: S-EPMC6311531 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Gao Zhizeng Z Thompson Andrew J AJ Paulson James C JC Withers Stephen G SG
Angewandte Chemie (International ed. in English) 20180914 41
Reagents to visualize and localize neuraminidase activity would be valuable probes to study the role of neuraminidases in normal cellular processes as well as during viral infections or cancer development. Herein, a new class of neuraminidase-imaging probes that function as proximity ligation reagents by releasing a highly reactive fluorophore that tags nearby cellular material is described. It is further demonstrated that it is possible to create an influenza virus-specific reagent, which can s ...[more]