Ontology highlight
ABSTRACT:
SUBMITTER: Pratt-Hyatt M
PROVIDER: S-EPMC3716307 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Pratt-Hyatt Matthew M Lickteig Andrew J AJ Klaassen Curtis D CD
Drug metabolism and disposition: the biological fate of chemicals 20130509 8
Aldo-keto reductases (Akrs) are a conserved group of NADPH-dependent oxido-reductase enzymes. This study provides a comprehensive examination of the tissue distribution of the 16 substrate-metabolizing Akrs in mice, their expression during development, and whether they are altered by chemicals that activate distinct transcriptional factor pathways. Akr1c6, 1c14, 1c20, and 1c22 are primarily present in liver; Akr1a4, 1c18, 1c21, and 7a5 in kidney; Akr1d1 in liver and kidney; Akr1b7 in small intes ...[more]