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ABSTRACT: Background
Studies investigating the association between single-nucleotide polymorphisms (SNPs) of the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and cancer risk report conflicting results. To derive a more precise estimation of the relationship between MTHFD1 polymorphisms and cancer risk, the present meta-analysis was carried out.Methodology/principal findings
A comprehensive search was conducted to determine all the eligible studies about MTHFD1 polymorphisms and cancer risk. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association between the MTHFD1 polymorphisms and cancer risk. We investigated by meta-analysis the effects of 2 polymorphisms in MTHFD1: G1958A (17 studies, 12348 cases, 44132 controls) and G401A (20 studies, 8446 cases, 14020 controls). The overall results indicated no major influence of these 2 polymorphisms on cancer risk. For G1958A, a decreased cancer risk was found in acute lymphoblastic leukemia (ALL)/Asians (the dominant: OR?=?0.74, 95% CI?=?0.58-0.94, P?=?0.01; allelic: OR?=?0.80, 95% CI?=?0.65-0.99, P?=?0.04) and other cancers (recessive: OR?=?0.80, 95% CI?=?0.66-0.96, P?=?0.02). For G401A, the data showed that MTHFD1 G401A polymorphism was associated with a decreased colon cancer risk under dominant model (OR?=?0.89, 95% CI?=?0.80-0.99, P?=?0.04).Conclusions
The results suggest that MTHFD1 G1958A polymorphism might be associated with a decreased risk of ALL and other cancers. Meanwhile, the MTHFD1 G401A might play a protective role in the development of colon cancer. Large-scale and well-designed case-control studies are necessary to validate the risk identified in the present meta-analysis.
SUBMITTER: Zhang H
PROVIDER: S-EPMC3716643 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhang Hongtuan H Ma Hui H Li Liang L Zhang Zhihong Z Xu Yong Y
PloS one 20130719 7
<h4>Background</h4>Studies investigating the association between single-nucleotide polymorphisms (SNPs) of the methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and cancer risk report conflicting results. To derive a more precise estimation of the relationship between MTHFD1 polymorphisms and cancer risk, the present meta-analysis was carried out.<h4>Methodology/principal findings</h4>A comprehensive search was conducted to determine all the eligible studies about MTHFD1 polymorphisms and cance ...[more]