Toward understanding the genetics of regulatory T cells in ovarian cancer.
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ABSTRACT:
SUBMITTER: Derycke MS
PROVIDER: S-EPMC3716752 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Toward understanding the genetics of regulatory T cells in ovarian cancer.
Derycke Melissa S MS Charbonneau Bridget B Preston Claudia C CC Kalli Kimberly R KR Knutson Keith L KL Rider David N DN Goode Ellen L EL
Oncoimmunology 20130416 6
Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape. ...[more]
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