Bromodomain proteins in HIV infection.
Ontology highlight
ABSTRACT:
SUBMITTER: Boehm D
PROVIDER: S-EPMC3717722 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Bromodomain proteins in HIV infection.
Boehm Daniela D Conrad Ryan J RJ Ott Melanie M
Viruses 20130621 6
Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse aspects of the HIV life cycle, including transcription and integration. Here, we review the role of bromodomain-containing proteins in HIV infection. We begin with a focus on acetylated viral factors, followed by a discussion of structural and biolog ...[more]
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