The IFITM proteins inhibit HIV-1 infection.
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ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC3067758 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
The IFITM proteins inhibit HIV-1 infection.
Lu Jennifer J Pan Qinghua Q Rong Liwei L He Wei W Liu Shan-Lu SL Liang Chen C
Journal of virology 20101222 5
Type I interferon protects cells from virus infection through the induction of a group of genes collectively named interferon-stimulated genes (ISGs). In this study, we utilized short hairpin RNA (shRNA) to deplete ISGs in SupT1 cells in order to identify ISGs that suppress the production of human immunodeficiency virus type 1 (HIV-1). Among the ISG candidates thus identified were interferon-induced transmembrane (IFITM) proteins, including IFITM1, IFITM2, and IFITM3, that potently inhibit HIV-1 ...[more]
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