Ontology highlight
ABSTRACT:
SUBMITTER: Shi L
PROVIDER: S-EPMC3718047 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Shi Lei L Butt Busma B Ip Fanny C F FC Dai Ying Y Jiang Liwen L Yung Wing-Ho WH Greenberg Michael E ME Fu Amy K Y AK Ip Nancy Y NY
Neuron 20100101 2
The maturation of neuromuscular junctions (NMJs) requires the topological transformation of postsynaptic acetylcholine receptor (AChR)-containing structures from a simple plaque to an elaborate structure composed of pretzel-like branches. This maturation process results in the precise apposition of the presynaptic and postsynaptic specializations. However, little is known about the molecular mechanisms underlying the plaque-to-pretzel transition of AChR clusters. In this study, we identify an es ...[more]