Ontology highlight
ABSTRACT:
SUBMITTER: Powers ET
PROVIDER: S-EPMC3718298 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Powers Evan T ET Balch William E WE
Nature reviews. Molecular cell biology 20130306 4
Although the sequence of a protein largely determines its function, proteins can adopt different folding states in response to changes in the environment, some of which may be deleterious to the organism. All organisms--Bacteria, Archaea and Eukarya--have evolved a protein homeostasis, or proteostasis, network comprising chaperones and folding factors, degradation components, signalling pathways and specialized compartmentalized modules that manage protein folding in response to environmental st ...[more]