Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto ML
PROVIDER: S-EPMC3718495 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Yamamoto Mitsuko L ML Maier Irene I Dang Angeline Tilly AT Berry David D Liu Jared J Ruegger Paul M PM Yang Jiue-In JI Soto Phillip A PA Presley Laura L LL Reliene Ramune R Westbrook Aya M AM Wei Bo B Loy Alexander A Chang Christopher C Braun Jonathan J Borneman James J Schiestl Robert H RH
Cancer research 20130701 14
Ataxia-telangiectasia is a genetic disorder associated with high incidence of B-cell lymphoma. Using an ataxia-telangiectasia mouse model, we compared lymphoma incidence in several isogenic mouse colonies harboring different bacterial communities, finding that intestinal microbiota are a major contributor to disease penetrance and latency, lifespan, molecular oxidative stress, and systemic leukocyte genotoxicity. High-throughput sequence analysis of rRNA genes identified mucosa-associated bacter ...[more]