Ontology highlight
ABSTRACT:
SUBMITTER: Knævelsrud H
PROVIDER: S-EPMC3718966 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Knævelsrud Helene H Søreng Kristiane K Raiborg Camilla C Håberg Karin K Rasmuson Fredrik F Brech Andreas A Liestøl Knut K Rusten Tor Erik TE Stenmark Harald H Neufeld Thomas P TP Carlsson Sven R SR Simonsen Anne A
The Journal of cell biology 20130701 2
The membrane remodeling events required for autophagosome biogenesis are still poorly understood. Because PX domain proteins mediate membrane remodeling and trafficking, we conducted an imaging-based siRNA screen for autophagosome formation targeting human PX proteins. The PX-BAR protein SNX18 was identified as a positive regulator of autophagosome formation, and its Drosophila melanogaster homologue SH3PX1 was found to be required for efficient autophagosome formation in the larval fat body. We ...[more]