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New insights into BAR domain-induced membrane remodeling.

ABSTRACT: Mesoscopic simulations and electron microscopy of N-BAR domain-induced liposome remodeling are used to characterize the process of liposome tubulation and vesiculation. The overall process of membrane remodeling is found to involve complex couplings among the N-BAR protein density, the degree of N-BAR oligomerization, and the membrane density. A comparison of complex remodeled liposome structures from mesoscopic simulations with those measured by electron microscopy experiments suggests that the process of membrane remodeling can be described via an appropriate mesoscopic free energy framework. Liposome remodeling more representative of F-BAR domains is also presented within the mesoscopic simulation framework.

SUBMITTER: Ayton GS

PROVIDER: S-EPMC2749773 | biostudies-other | 2009 Sep

REPOSITORIES: biostudies-other

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New insights into BAR domain-induced membrane remodeling.

Ayton Gary S GS Lyman Edward E Krishna Vinod V Swenson Richard D RD Mim Carsten C Unger Vinzenz M VM Voth Gregory A GA

Biophysical journal 20090901 6

Mesoscopic simulations and electron microscopy of N-BAR domain-induced liposome remodeling are used to characterize the process of liposome tubulation and vesiculation. The overall process of membrane remodeling is found to involve complex couplings among the N-BAR protein density, the degree of N-BAR oligomerization, and the membrane density. A comparison of complex remodeled liposome structures from mesoscopic simulations with those measured by electron microscopy experiments suggests that the ...[more]

PMID: 19751666

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