Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez G
PROVIDER: S-EPMC3719689 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Hernández Greco G Miron Mathieu M Han Hong H Liu Niankun N Magescas Jérémy J Tettweiler Gritta G Frank Filipp F Siddiqui Nadeem N Sonenberg Nahum N Lasko Paul P
Molecular and cellular biology 20130528 15
Translation is a fundamental step in gene expression, and translational control is exerted in many developmental processes. Most eukaryotic mRNAs are translated by a cap-dependent mechanism, which requires recognition of the 5'-cap structure of the mRNA by eukaryotic translation initiation factor 4E (eIF4E). eIF4E activity is controlled by eIF4E-binding proteins (4E-BPs), which by competing with eIF4G for eIF4E binding act as translational repressors. Here, we report the discovery of Mextli (Mxt ...[more]