Ontology highlight
ABSTRACT:
SUBMITTER: Gallagher EE
PROVIDER: S-EPMC6679956 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Gallagher Erin E EE Song James M JM Menon Arya A Mishra Lauren D LD Chmiel Alyah F AF Garner Amanda L AL
Journal of medicinal chemistry 20190509 10
Protein disorder plays a crucial role in signal transduction and is key for many cellular processes including transcription, translation, and cell cycle. Within the intrinsically disordered protein interactome, the α-helix is commonly used for binding, which is induced via a disorder-to-order transition. Because the targeting of protein-protein interactions (PPIs) remains an important challenge in medicinal chemistry, efforts have been made to mimic this secondary structure for rational inhibito ...[more]