Ontology highlight
ABSTRACT:
SUBMITTER: Wang FF
PROVIDER: S-EPMC3720085 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wang Fei-Fei FF Wang Qian Q Chen Yong Y Lin Qiang Q Gao Hui-Bao HB Zhang Ping P
Asian journal of andrology 20120521 4
Several studies have suggested that stress and ageing exert inhibitory effects on rat Leydig cells. In a pattern similar to the normal process of Leydig cell ageing, stress-mediated increases in glucocorticoid levels inhibit steroidogenic enzyme expression that then results in decreased testosterone secretion. We hypothesized that chronic stress accelerates the degenerative changes associated with ageing in Leydig cells. To test this hypothesis, we established a model of chronic stress to evalua ...[more]