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Four new briarane diterpenoids from Taiwanese gorgonian Junceella fragilis.

ABSTRACT: Four new 8-hydroxybriarane diterpenoids, frajunolides P-S (1-4), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, including 1D- and 2D-NMR, as well as HRMS data. Compound 1 was further confirmed by X-ray crystallographic analysis. In the anti-inflammatory test, compounds 1 and 2 exhibited moderate inhibition on superoxide anion generation and elastase release by human neutrophils in response to formylmethionylleucyl-phenylalanine/dihydrocytochalasin B (fMLP/CB).

SUBMITTER: Liaw CC

PROVIDER: S-EPMC3721220 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Four new briarane diterpenoids from Taiwanese gorgonian Junceella fragilis.

Liaw Chia-Ching CC Lin Yu-Chi YC Lin Yun-Sheng YS Chen Chung-Hsiung CH Hwang Tsong-Long TL Shen Ya-Ching YC

Marine drugs 20130610 6

Four new 8-hydroxybriarane diterpenoids, frajunolides P-S (1-4), together with umbraculolide A, juncenolide C, junceellonoid A and juncin R, were isolated from the acetone extract of the gorgonian Junceella fragilis, collected from the southeast coast of Taiwan. Compound 1 contains an unusual pivaloyloxy group at C-2, while 3 is a rare compound having a chlorine atom on the olefinic carbon (C-6). The structures of the isolated compounds were established by extensive spectroscopic analysis, inclu ...[more]

PMID: 23752357

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