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New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae).

ABSTRACT: Two new 11,20-epoxybriaranes, fragilides P (1) and Q (2), as well as two known analogues, robustolide F (3) and juncin Z (4), were obtained from the gorgonian coral Junceella fragilis. The structures, including the absolute configurations of briaranes 1 and 2, were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane 4 decreased the generation of superoxide anions by human neutrophils. The propionate group in 1 is rarely found.

SUBMITTER: Lin CC

PROVIDER: S-EPMC6659381 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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New 11,20-Epoxybriaranes from the Gorgonian Coral Junceella fragilis (Ellisellidae).

Lin Chia-Cheng CC Su Jui-Hsin JH Chen Wu-Fu WF Wen Zhi-Hong ZH Peng Bo-Rong BR Huang Lin-Cyuan LC Hwang Tsong-Long TL Sung Ping-Jyun PJ

Molecules (Basel, Switzerland) 20190707 13

Two new 11,20-epoxybriaranes, fragilides P (1) and Q (2), as well as two known analogues, robustolide F (3) and juncin Z (4), were obtained from the gorgonian coral Junceella fragilis. The structures, including the absolute configurations of briaranes 1 and 2, were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane 4 decreased the generation of superoxi ...[more]

PMID: 31284657

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