Ontology highlight
ABSTRACT:
SUBMITTER: Denic V
PROVIDER: S-EPMC3721280 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Denic Vladimir V Dötsch Volker V Sinning Irmgard I
Cold Spring Harbor perspectives in biology 20130801 8
Hundreds of eukaryotic membrane proteins are anchored to membranes by a single transmembrane domain at their carboxyl terminus. Many of these tail-anchored (TA) proteins are posttranslationally targeted to the endoplasmic reticulum (ER) membrane for insertion by the guided-entry of TA protein insertion (GET) pathway. In recent years, most of the components of this conserved pathway have been biochemically and structurally characterized. Get3 is the pathway-targeting factor that uses nucleotide-l ...[more]