Ontology highlight
ABSTRACT:
SUBMITTER: Van Emburgh BO
PROVIDER: S-EPMC3722359 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Van Emburgh Beth O BO Hu Jennifer J JJ Levine Edward A EA Mosley Libyadda J LJ Case L Douglas LD Lin Hui-Yi HY Knight Sommer N SN Perrier Nancy D ND Rubin Peter P Sherrill Gary B GB Shaw Cindy S CS Carey Lisa A LA Sawyer Lynda R LR Allen Glenn O GO Milikowski Clara C Willingham Mark C MC Miller Mark Steven MS
Molecular carcinogenesis 20080201 2
Polymorphisms in phase I and phase II enzymes may enhance the occurrence of mutations at critical tumor suppressor genes, such as p53, and increase breast cancer risk by either increasing the activation or detoxification of carcinogens and/or endogenous estrogens. We analyzed polymorphisms in CYP1B1, GSTM1, GSTT1, and GSTP1 and p53 mutations in 323 breast tumor samples. Approximately 11% of patients exhibited mutations in p53. Women with mutations had a significantly younger age of diagnosis (P ...[more]