Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez LI
PROVIDER: S-EPMC3722562 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Hernandez Luiza I LI Flenker Katie S KS Hernandez Frank J FJ Klingelhutz Aloysius J AJ McNamara James O JO Giangrande Paloma H PH
Pharmaceuticals (Basel, Switzerland) 20130301 3
Recent clinical trials of small interfering RNAs (siRNAs) highlight the need for robust delivery technologies that will facilitate the successful application of these therapeutics to humans. Arguably, cell targeting by conjugation to cell-specific ligands provides a viable solution to this problem. Synthetic RNA ligands (aptamers) represent an emerging class of pharmaceuticals with great potential for targeted therapeutic applications. For targeted delivery of siRNAs with aptamers, the aptamer-s ...[more]