Ontology highlight
ABSTRACT:
SUBMITTER: Sczepanski JT
PROVIDER: S-EPMC4703082 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Sczepanski Jonathan T JT Joyce Gerald F GF
Journal of the American Chemical Society 20151221 51
In vitro selection was used to obtain l-RNA aptamers that bind the distal stem-loop of various precursor microRNAs (pre-miRs). These l-aptamers, termed "aptamiRs", bind their corresponding pre-miR target through highly specific tertiary interactions rather than Watson-Crick pairing. Formation of a pre-miR-aptamiR complex inhibits Dicer-mediated processing of the pre-miR, which is required to form the mature functional microRNA. One of the aptamiRs, which was selected to bind oncogenic pre-miR-15 ...[more]