Dataset Information

Strain history dependence of the nonlinear stress response of fibrin and collagen networks.

ABSTRACT: We show that the nonlinear mechanical response of networks formed from un-cross-linked fibrin or collagen type I continually changes in response to repeated large-strain loading. We demonstrate that this dynamic evolution of the mechanical response arises from a shift of a characteristic nonlinear stress-strain relationship to higher strains. Therefore, the imposed loading does not weaken the underlying matrices but instead delays the occurrence of the strain stiffening. Using confocal microscopy, we present direct evidence that this behavior results from persistent lengthening of individual fibers caused by an interplay between fiber stretching and fiber buckling when the networks are repeatedly strained. Moreover, we show that covalent cross-linking of fibrin or collagen inhibits the shift of the nonlinear material response, suggesting that the molecular origin of individual fiber lengthening may be slip of monomers within the fibers. Thus, a fibrous architecture in combination with constituents that exhibit internal plasticity creates a material whose mechanical response adapts to external loading conditions. This design principle may be useful to engineer novel materials with this capability.

SUBMITTER: Munster S

PROVIDER: S-EPMC3725119 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Strain history dependence of the nonlinear stress response of fibrin and collagen networks.

Münster Stefan S Jawerth Louise M LM Leslie Beverly A BA Weitz Jeffrey I JI Fabry Ben B Weitz David A DA

Proceedings of the National Academy of Sciences of the United States of America 20130610 30

We show that the nonlinear mechanical response of networks formed from un-cross-linked fibrin or collagen type I continually changes in response to repeated large-strain loading. We demonstrate that this dynamic evolution of the mechanical response arises from a shift of a characteristic nonlinear stress-strain relationship to higher strains. Therefore, the imposed loading does not weaken the underlying matrices but instead delays the occurrence of the strain stiffening. Using confocal microscop ...[more]

PMID: 23754380

Similar Datasets

Project description:The most common process variable available for analysis due to tests presented in a computerized form is response time. Psychometric models have been developed for joint modeling of response accuracy and response time in which response time is an additional source of information about ability and about the underlying response processes. While traditional models assume conditional independence between response time and accuracy given ability and speed latent variables (van der Linden, 2007), recently multiple studies (De Boeck and Partchev, 2012; Meng et al., 2015; Bolsinova et al., 2017a,b) have shown that violations of conditional independence are not rare and that there is more to learn from the conditional dependence between response time and accuracy. When it comes to conditional dependence between time and accuracy, authors typically focus on positive conditional dependence (i.e., relatively slow responses are more often correct) and negative conditional dependence (i.e., relatively fast responses are more often correct), which implies monotone conditional dependence. Moreover, most existing models specify the relationship to be linear. However, this assumption of monotone and linear conditional dependence does not necessarily hold in practice, and assuming linearity might distort the conclusions about the relationship between time and accuracy. In this paper we develop methods for exploring nonlinear conditional dependence between response time and accuracy. Three different approaches are proposed: (1) A joint model for quadratic conditional dependence is developed as an extension of the response moderation models for time and accuracy (Bolsinova et al., 2017b); (2) A joint model for multiple-category conditional dependence is developed as an extension of the fast-slow model of Partchev and De Boeck (2012); (3) An indicator-level nonparametric moderation method (Bolsinova and Molenaar, in press) is used with residual log-response time as a predictor for the item intercept and item slope. Furthermore, we propose using nonparametric moderation to evaluate the viability of the assumption of linearity of conditional dependence by performing posterior predictive checks for the linear conditional dependence model. The developed methods are illustrated using data from an educational test in which, for the majority of the items, conditional dependence is shown to be nonlinear.

Dataset Information

Strain history dependence of the nonlinear stress response of fibrin and collagen networks.

Publications

Strain history dependence of the nonlinear stress response of fibrin and collagen networks.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure