Ontology highlight
ABSTRACT:
SUBMITTER: Munster S
PROVIDER: S-EPMC3725119 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Münster Stefan S Jawerth Louise M LM Leslie Beverly A BA Weitz Jeffrey I JI Fabry Ben B Weitz David A DA
Proceedings of the National Academy of Sciences of the United States of America 20130610 30
We show that the nonlinear mechanical response of networks formed from un-cross-linked fibrin or collagen type I continually changes in response to repeated large-strain loading. We demonstrate that this dynamic evolution of the mechanical response arises from a shift of a characteristic nonlinear stress-strain relationship to higher strains. Therefore, the imposed loading does not weaken the underlying matrices but instead delays the occurrence of the strain stiffening. Using confocal microscop ...[more]