Ontology highlight
ABSTRACT:
SUBMITTER: Gyekis JP
PROVIDER: S-EPMC3725128 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Gyekis Joseph P JP Yu Weihong W Dong Shuqian S Wang Haina H Qian Jun J Kota Pravina P Yang Jingyun J
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20121126 1
Major depressive disorder (MDD) is a complex psychiatric condition with strong genetic predisposition. The association of MDD with genetic polymorphisms, such as Val66Met (rs6265), in the brain derived neurotrophic factor (BDNF), have been reported in many studies and the results were conflicting. In this study, we performed a systematic literature search and conducted random-effects meta-analysis to evaluate genetic variants in BDNF with MDD. A gene-based analysis was also conducted to investig ...[more]