Ontology highlight
ABSTRACT:
SUBMITTER: Cino EA
PROVIDER: S-EPMC3725505 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cino Elio A EA Killoran Ryan C RC Karttunen Mikko M Choy Wing-Yiu WY
Scientific reports 20130101
A small number of proteins, called hubs, have high connectivity and are essential for interactome functionality and integrity. Keap1 is a crucial hub in the oxidative stress response and apoptosis. The Kelch domain of Keap1 preferentially binds to disordered regions of its partners, which share similar binding motifs, but have a wide range of binding affinities. Isothermal titration calorimetry (ITC) and multi-microsecond molecular dynamics (MD) simulations were used to determine the factors tha ...[more]