Fuzzy protein theory for disordered proteins.
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ABSTRACT:
SUBMITTER: Fuxreiter M
PROVIDER: S-EPMC7752076 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Fuzzy protein theory for disordered proteins.
Biochemical Society transactions 20201201 6
Why proteins are fuzzy? Constant adaptation to the cellular environment requires a wide range of changes in protein structure and interactions. Conformational ensembles of disordered proteins in particular exhibit large shifts to activate or inhibit alternative pathways. Fuzziness is critical for liquid-liquid phase separation and conversion of biomolecular condensates into fibrils. Interpretation of these phenomena presents a challenge for the classical structure-function paradigm. Here I discu ...[more]
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