Immunogenetics of spontaneous control of HIV.
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ABSTRACT:
SUBMITTER: Carrington M
PROVIDER: S-EPMC3725592 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Immunogenetics of spontaneous control of HIV.
Carrington Mary M Walker Bruce D BD
Annual review of medicine 20120101
Host genetic variation is presently estimated to account for about one-fourth of the observed differences in control of HIV across infected individuals. Genome-wide association studies have confirmed that polymorphism within the HLA class I locus is the primary host genetic contributor to determining outcome after infection. Here we progress beyond the genetic associations alone to consider the functional explanations for these correlations. In this process, the complex and multidimensional effe ...[more]
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