Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3725990 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Li Hongmei H Alavian Kambiz N KN Lazrove Emma E Mehta Nabil N Jones Adrienne A Zhang Ping P Licznerski Pawel P Graham Morven M Uo Takuma T Guo Junhua J Rahner Christoph C Duman Ronald S RS Morrison Richard S RS Jonas Elizabeth A EA
Nature cell biology 20130623 7
Following exocytosis, the rate of recovery of neurotransmitter release is determined by vesicle retrieval from the plasma membrane and by recruitment of vesicles from reserve pools within the synapse, which is dependent on mitochondrial ATP. The anti-apoptotic Bcl-2 family protein Bcl-xL also regulates neurotransmitter release and recovery in part by increasing ATP availability from mitochondria. We now find, that Bcl-xL directly regulates endocytic vesicle retrieval in hippocampal neurons throu ...[more]