Ontology highlight
ABSTRACT:
SUBMITTER: Schisler JC
PROVIDER: S-EPMC3726173 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Schisler Jonathan C JC Rubel Carrie E CE Zhang Chunlian C Lockyer Pamela P Cyr Douglas M DM Patterson Cam C
The Journal of clinical investigation 20130725 8
Protein quality control and metabolic homeostasis are integral to maintaining cardiac function during stress; however, little is known about if or how these systems interact. Here we demonstrate that C terminus of HSC70-interacting protein (CHIP), a regulator of protein quality control, influences the metabolic response to pressure overload by direct regulation of the catalytic α subunit of AMPK. Induction of cardiac pressure overload in Chip-/- mice resulted in robust hypertrophy and decreased ...[more]