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High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart.

ABSTRACT: A technique on high frame rate(28fps), high frequency co-registered ultrasound and photoacoustic imaging for visualizing zebrafish heart blood flow was demonstrated. This approach was achieved with a 40MHz light weight(0.38g) ring-type transducer, serving as the ultrasound transmitter and receiver, to allow an optic fiber, coupled with a 532nm laser, to be inserted into the hole. From the wire target study, axial resolutions of 38µm and 42µm were obtained for ultrasound and photoacoustic imaging, respectively. Carbon nanotubes were utilized as contrast agents to increase the flow signal level by 20dB in phantom studies, and zebrafish heart blood flow was successfully observed.

SUBMITTER: Park J

PROVIDER: S-EPMC3726247 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart.

Park Jinhyoung J Cummins Thomas M TM Harrison Michael M Lee Jungwoo J Zhou Qifa Q Lien Ching-Ling CL Shung K Kirk KK

Optics express 20130601 12

A technique on high frame rate(28fps), high frequency co-registered ultrasound and photoacoustic imaging for visualizing zebrafish heart blood flow was demonstrated. This approach was achieved with a 40MHz light weight(0.38g) ring-type transducer, serving as the ultrasound transmitter and receiver, to allow an optic fiber, coupled with a 532nm laser, to be inserted into the hole. From the wire target study, axial resolutions of 38µm and 42µm were obtained for ultrasound and photoacoustic imaging ...[more]

PMID: 23787651

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