Ontology highlight
ABSTRACT:
SUBMITTER: Nikitopoulou I
PROVIDER: S-EPMC3726599 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nikitopoulou Ioanna I Kaffe Eleanna E Sevastou Ioanna I Sirioti Ivi I Samiotaki Martina M Madan Damian D Prestwich Glenn D GD Aidinis Vassilis V
PloS one 20130729 7
Rheumatoid arthritis (RA) is a destructive arthropathy with systemic manifestations, characterized by chronic synovial inflammation. Under the influence of the pro-inflammatory milieu synovial fibroblasts (SFs), the main effector cells in disease pathogenesis become activated and hyperplastic while releasing a number of signals that include pro-inflammatory factors and tissue remodeling enzymes. Activated RA SFs in mouse or human arthritic joints express significant quantities of autotaxin (ATX) ...[more]