Ontology highlight
ABSTRACT:
SUBMITTER: Chen YL
PROVIDER: S-EPMC3726622 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chen Yu-Ling YL Wang Ting-Huang TH Hsu Hey-Chi HC Yuan Ray-Hwang RH Jeng Yung-Ming YM
PloS one 20130729 7
Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein that activates the planar cell polarity pathway of Wnt signaling. Using microarray analysis, we found that the CTHRC1 gene is overexpressed in hepatocellular carcinoma (HCC). The level of CTHRC1 mRNA was measured in 201 surgically resected HCCs using real time reverse transcription-polymerase chain reaction. Overexpression of CTHRC1 in HCC was associated with large tumor size and advanced tumor stage. Furthermore, expr ...[more]