Ontology highlight
ABSTRACT:
SUBMITTER: Huang S
PROVIDER: S-EPMC7041778 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Huang Shanzhou S Zhang Chuanzhao C Sun Chengjun C Hou Yuchen Y Zhang Yixi Y Tam Nga Lei NL Wang Zekang Z Yu Jia J Huang Bowen B Zhuang Hongkai H Zhou Zixuan Z Ma Zuyi Z Sun Zhonghai Z He Xiaoshun X Zhou Qi Q Hou Baohua B Wu Linwei L
Aging 20200211 3
<h4>Background</h4>Obg-like ATPase 1 (OLA1) has been found to have a dual role in cancers. However, the relationship between OLA1 and hepatocellular carcinoma (HCC) remains unclear.<h4>Results</h4>High expression of OLA1 in HCC was detected in public datasets and clinical samples, and correlated with poor prognosis. Downregulation of OLA1 significantly inhibited the proliferation, migration, invasion and tumorigenicity of HCC cells. Mechanistically, GSEA showed that OLA1 might promote tumor prog ...[more]