Ontology highlight
ABSTRACT:
SUBMITTER: Huang L
PROVIDER: S-EPMC3726718 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Huang Lili L Serganov Alexander A Patel Dinshaw J DJ
Molecular cell 20101201 5
Glycine riboswitches regulate gene expression by feedback modulation in response to cooperative binding to glycine. Here, we report on crystal structures of the second glycine-sensing domain from the Vibrio cholerae riboswitch in the ligand-bound and unbound states. This domain adopts a three-helical fold that centers on a three-way junction and accommodates glycine within a bulge-containing binding pocket above the junction. Glycine recognition is facilitated by a pair of bound Mg(2+) cations a ...[more]