Ontology highlight
ABSTRACT:
SUBMITTER: Gao A
PROVIDER: S-EPMC4294798 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Gao Ang A Serganov Alexander A
Nature chemical biology 20140803 9
Bacterial second messenger cyclic di-AMP (c-di-AMP) is implicated in signaling DNA damage and cell wall stress through interactions with several protein receptors and a widespread ydaO-type riboswitch. We report the crystal structures of c-di-AMP riboswitches from Thermoanaerobacter pseudethanolicus and Thermovirga lienii determined at ∼3.0-Å resolution. In both species, the RNA adopts an unforeseen 'square'-shaped pseudosymmetrical architecture that features two three-way junctions, a turn and ...[more]