Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer.

ABSTRACT:

Purpose

Although breast cancers are known to be molecularly heterogeneous, their metabolic phenotype is less well-understood and may predict response to chemotherapy. This study aimed to evaluate metabolic genes as individual predictive biomarkers in breast cancer.

Experimental design

mRNA microarray data from breast cancer cell lines were used to identify bimodal genes-those with highest potential for robust high/low classification in clinical assays. Metabolic function was evaluated in vitro for the highest scoring metabolic gene, lactate dehydrogenase B (LDHB). Its expression was associated with neoadjuvant chemotherapy response and relapse within clinical and PAM50-derived subtypes.

Results

LDHB was highly expressed in cell lines with glycolytic, basal-like phenot

SUBMITTER: Dennison JB 

PROVIDER: S-EPMC3727144 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature