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Design and synthesis of mimics of the T7-loop of FtsZ.

ABSTRACT: Mimics of the T7-loop of the bacterial cell division protein FtsZ have been designed and synthesized. The design is based on the X-ray cocrystal structure of P. aeruginosa FtsZ:SulA. Fast Rigid Exhaustive Docking (FRED) was employed to select compounds that can mimic the key interacting residues. Bicyclic oxazolidinones 1a-d were selected for further study and synthesized from a key bicyclic aziridine intermediate, which is synthesized from a readily available unsaturated aldehyde and amides derived from ?-amino acids.

SUBMITTER: Sorto NA

PROVIDER: S-EPMC3727220 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Design and synthesis of mimics of the T7-loop of FtsZ.

Sorto Nohemy A NA Painter Phillip P PP Fettinger James C JC Tantillo Dean J DJ Shaw Jared T JT

Organic letters 20130530 11

Mimics of the T7-loop of the bacterial cell division protein FtsZ have been designed and synthesized. The design is based on the X-ray cocrystal structure of P. aeruginosa FtsZ:SulA. Fast Rigid Exhaustive Docking (FRED) was employed to select compounds that can mimic the key interacting residues. Bicyclic oxazolidinones 1a-d were selected for further study and synthesized from a key bicyclic aziridine intermediate, which is synthesized from a readily available unsaturated aldehyde and amides der ...[more]

PMID: 23721122

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