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Selective cavitand-mediated endocytosis of targeted imaging agents into live cells.


ABSTRACT: A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis of a specifically tagged target molecule in different types of living human cells. The presence of suitable choline-derived binding handles is essential for the molecular recognition and transport process, allowing selective guest transport and imaging of cancer cells.

SUBMITTER: Ghang YJ 

PROVIDER: S-EPMC3727974 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Selective cavitand-mediated endocytosis of targeted imaging agents into live cells.

Ghang Yoo-Jin YJ   Schramm Michael P MP   Zhang Fan F   Acey Roger A RA   David Clement N CN   Wilson Emma H EH   Wang Yinsheng Y   Cheng Quan Q   Hooley Richard J RJ  

Journal of the American Chemical Society 20130430 19


A water-soluble synthetic receptor molecule is capable of selective, controlled endocytosis of a specifically tagged target molecule in different types of living human cells. The presence of suitable choline-derived binding handles is essential for the molecular recognition and transport process, allowing selective guest transport and imaging of cancer cells. ...[more]

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