Ontology highlight
ABSTRACT:
SUBMITTER: Uddin MJ
PROVIDER: S-EPMC2864539 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Uddin Md Jashim MJ Crews Brenda C BC Blobaum Anna L AL Kingsley Philip J PJ Gorden D Lee DL McIntyre J Oliver JO Matrisian Lynn M LM Subbaramaiah Kotha K Dannenberg Andrew J AJ Piston David W DW Marnett Lawrence J LJ
Cancer research 20100501 9
Effective diagnosis of inflammation and cancer by molecular imaging is challenging because of interference from nonselective accumulation of the contrast agents in normal tissues. Here, we report a series of novel fluorescence imaging agents that efficiently target cyclooxygenase-2 (COX-2), which is normally absent from cells, but is found at high levels in inflammatory lesions and in many premalignant and malignant tumors. After either i.p. or i.v. injection, these reagents become highly enrich ...[more]