Ontology highlight
ABSTRACT:
SUBMITTER: Beck IM
PROVIDER: S-EPMC3728325 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Beck Ilse M IM Drebert Zuzanna J ZJ Hoya-Arias Ruben R Bahar Ali A AA Devos Michael M Clarisse Dorien D Desmet Sofie S Bougarne Nadia N Ruttens Bart B Gossye Valerie V Denecker Geertrui G Lievens Sam S Bracke Marc M Tavernier Jan J Declercq Wim W Gevaert Kris K Vanden Berghe Wim W Haegeman Guy G De Bosscher Karolien K
PloS one 20130730 7
Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger glucocorticoid response element-regulated gene expression. The heat shock response potently activates heat shock factor 1 (HSF1), upregulates Hsp70, a known GR chaperone, and also modulates various aspects of inflammation. We found that the selective GR m ...[more]