Ontology highlight
ABSTRACT:
SUBMITTER: Webb DR
PROVIDER: S-EPMC3729224 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Webb David R DR Handel Tracy M TM Kretz-Rommel Anke A Stevens Raymond C RC
Biochemical pharmacology 20120910 2
Monoclonal antibodies (mAbs) have been used for decades as tools to probe the biology and pharmacology of receptors in cells and tissues. They are also increasingly being developed for clinical purposes against a broad range of targets, albeit to a lesser extent for G-protein-coupled receptors (GPCRs) relative to other therapeutic targets. Recent pharmacological, structural and biophysical data have provided a great deal of new insight into the molecular details, complexity and regulation of GPC ...[more]