Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells.

ABSTRACT:

Background

Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated for anti-cancer activity. We investigated if PPD disrupts lipid rafts in its cytotoxic effects and also the possible mechanisms.

Methods

Eight ginsenosides were evaluated using different cancer cells and cell viability assays. The potent ginsenoside, PPD was investigated for its roles in lipid raft disruption and downstream pathways to apoptosis of cancer cells. Anti-cancer effects of PPD was also investigated in vivo using mouse xenograft model.

Results

PPD consistently exerts its potent cytotoxicity in

SUBMITTER: Park B 

PROVIDER: S-EPMC3729373 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature