Ontology highlight
ABSTRACT:
SUBMITTER: Yoo SW
PROVIDER: S-EPMC7852391 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Yoo Seung-Wan SW Agarwal Amit A Smith Matthew D MD Khuder Saja S SS Baxi Emily G EG Thomas Ajit G AG Rojas Camilo C Moniruzzaman Mohammed M Slusher Barbara S BS Bergles Dwight E DE Calabresi Peter A PA Haughey Norman J NJ
Science advances 20201002 40
Myelination requires a highly organized synthesis of multiple lipid species that regulate myelin curvature and compaction. For reasons that are not understood, central nervous system remyelinated axons often have thin myelin sheaths with a disorganized structure susceptible to secondary demyelination. We found that expression of the sphingomyelin hydrolase neutral sphingomyelinase 2 (nSMase2) during the differentiation of oligodendrocyte progenitor cells (OPCs) to myelinating oligodendrocytes ch ...[more]