Association of ITPA polymorphism with outcomes of peginterferon-α plus ribavirin combination therapy.

ABSTRACT:

Aim

To analyzed the association between inosine triphosphatase (ITPA) (rs1127354) genotypes and sustained virological response (SVR) rates in peginterferon (Peg-IFN)α + ribavirin (RBV) treatment.

Methods

Patients who underwent Peg-IFNα + RBV combination therapy were enrolled (n = 120) and they had no history of other IFN-based treatments. Variation in hemoglobin levels during therapy, cumulative reduction of RBV dose, frequency of treatment withdrawal, and SVR rates were investigated in each ITPA genotype.

Results

In patients with ITPA CC genotype, hemoglobin decline was significantly greater and the percentage of patients in whom total RBV dose was < 60% of standard and/or treatment was withdrawn was significantly higher compared with CA/AA genotype. However, SVR rat

SUBMITTER: Fujino T 

PROVIDER: S-EPMC3729868 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature