Unknown

Dataset Information

0

IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection.


ABSTRACT: The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway's immune response against various bacteria and fungal infection. Cytokines such as IL-23, which are involved in Th17 differentiation, play a critical role in controlling Klebsiella pneumonia (K. pneumonia) infection. IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. Mice deficient in IL-17 receptor (IL-17R) expression are susceptible to infection by various pathogens. In this review, we summarize the recent advances in unraveling the mechanism behind Th17 cell differentiation, IL-17A/IL-17R signaling, and also the importance of IL-17A in pulmonary infection.

SUBMITTER: Tsai HC 

PROVIDER: S-EPMC3730142 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection.

Tsai Hsing-Chuan HC   Velichko Sharlene S   Hung Li-Yin LY   Wu Reen R  

Clinical & developmental immunology 20130717


The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway's immune response against various bacteria and fungal infection. Cytokines such as IL-23, which are involved in Th17 differentiation, play a critical role in controlling Klebsiella pneumonia (K. pneumonia) infection. I  ...[more]

Similar Datasets

| S-EPMC5089371 | biostudies-literature
| S-EPMC3076054 | biostudies-literature
| S-EPMC4598415 | biostudies-literature
| S-EPMC6486355 | biostudies-literature
| S-EPMC5989851 | biostudies-literature
| S-EPMC4275066 | biostudies-literature
| S-EPMC5935094 | biostudies-literature
| S-EPMC6379809 | biostudies-literature
| S-EPMC4316398 | biostudies-other
| S-EPMC2901867 | biostudies-literature